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Article

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.

Development (Cambridge, England) - 1 Feb 2000

Yi S E, Daluiski A, Pederson R, Rosen V, Lyons K M

Abstract excerpt

Mice carrying a targeted disruption of BmprIB were generated by homologous recombination in embryonic stem cells. BmprIB(-/-) mice are viable and, in spite of the widespread expression of BMPRIB throughout the developing skeleton, exhibit defects that are largely restricted to the appendicular skeleton. Using molecular markers, we show that the initial formation of the digital rays occurs normally in null...

Read the complete abstract on PubMed

Topics

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Share to Bone and Bones
Share to Bone Morphogenetic Protein Receptors, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage, Articular

Share to Extremities

Share to Gene Expression Regulation, Developmental

Share to Osteogenesis

Share to Protein Serine-Threonine Kinases

Share to Receptors, Growth Factor

Source

Identifiers

PMID: 10631182
DOI: 10.1242/dev.127.3.621

Genes

BMP7
GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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