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Article

Common variants in PCSK1 influence blood pressure and body mass index.

Journal of human hypertension - 1 Feb 2015

Gu Q, Yazdanpanah M, van Hoek M, Hofman A, Gao X, de Rooij F W M, Sijbrands E J G

Abstract excerpt

Proprotein convertase subtilisin/kexin-type 1 (PCSK1) activates precursors pro-opiomelanocortin (POMC), proinsulin and prorenin. We investigated if common variants in the PCSK1 gene influence blood pressure and risk of hypertension. Additionally, we investigated the risk of obesity and type 2 diabetes (T2D). In the Rotterdam Study (RS1), a prospective, population-based cohort (n=5974), four single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25031086
DOI: 10.1038/jhh.2014.59

Genes

PCSK1
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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