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Article

PCSK1 Variants and Human Obesity.

Progress in molecular biology and translational science - 1 Jan 2016

Ramos-Molina B, Martin M G, Lindberg I

Abstract excerpt

PCSK1, encoding prohormone convertase 1/3 (PC1/3), was one of the first genes linked to monogenic early-onset obesity. PC1/3 is a protease involved in the biosynthetic processing of a variety of neuropeptides and prohormones in endocrine tissues. PC1/3 activity is essential for the activating cleavage of many peptide hormone precursors implicated in the regulation of food ingestion, glucose homeostasis, and...

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Identifiers

PMID: 27288825
DOI: 10.1016/bs.pmbts.2015.12.001
PMCID: PMC6082390

Genes

PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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