Article
Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion.
BMC medical genetics - 9 Jun 2010
Heni Martin, Haupt Axel, Schäfer Silke A, Ketterer Caroline, Thamer Claus, Machicao Fausto, Stefan Norbert, Staiger Harald, Häring Hans-Ulrich, Fritsche Andreas
Abstract excerpt
BACKGROUND: Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity. We studied whether these SNPs influence the prediabetic traits insulin...
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