The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis.

doi:10.1093/aje/kwu237

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Article

The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis.

American journal of epidemiology - 1 Dec 2014

Stijnen Pieter, Tuand Krizia, Varga Tibor V, Franks Paul W, Aertgeerts Bert, Creemers John W M

Abstract excerpt

Congenital deficiency of the proprotein convertase subtilisine/kexin type 1 gene (PCSK1), which encodes proprotein convertase 1/3, causes a severe multihormonal disorder marked by early-onset obesity. The single nucleotide polymorphisms (SNPs) rs6232 and rs6234-rs6235 in PCSK1 have been associated with obesity. However, case-control studies carried out in populations of different ethnicities have only partly...

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Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Associations and Epidemiology

Genomics and Rare Diseases

Lipoproteins and Cardiovascular Health

Obesity

Polymorphism, Single Nucleotide

Proprotein Convertase 1

Waist Circumference

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Open in PubMed

Identifiers

PMID: 25355447
DOI: 10.1093/aje/kwu237

Genes

PCSK1

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