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Article

Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism.

Molecular metabolism - 1 Mar 2017

Löffler Dennis, Behrendt Susanne, Creemers John W M, Klammt Jürgen, Aust Gabriela, Stanik Juraj, Kiess Wieland, Kovacs Peter, Körner Antje

Abstract excerpt

OBJECTIVE: Variants in Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) may be causative for obesity as suggested by monogenic cases and association studies. Here we assessed the functional relevance in experimental studies and the clinical relevance through detailed metabolic phenotyping of newly identified and known PCSK1 variants in children. RESULTS: In 52 obese children selected for elevated proinsulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28271036
DOI: 10.1016/j.molmet.2016.12.002
PMCID: PMC5323889

Genes

PCSK1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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