Article
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.
Human molecular genetics - 15 Jun 2015
Nead Kevin T, Li Aihua, Wehner Mackenzie R, Neupane Binod, Gustafsson Stefan, Butterworth Adam, Engert James C, Davis A Darlene, Hegele Robert A, Miller Ruby, den Hoed Marcel, Khaw Kay-Tee, Kilpeläinen Tuomas O, Wareham Nick, Edwards Todd L, Hallmans Göran, Varga Tibor V, Kardia Sharon L R, Smith Jennifer A, Zhao Wei, Faul Jessica D, Weir David, Mi Jie, Xi Bo, Quinteros Samuel Canizales, Cooper Cyrus, Sayer Avan Aihie, Jameson Karen, Grøntved Anders, Fornage Myriam, Sidney Stephen, Hanis Craig L, Highland Heather M, Häring Hans-Ulrich, Heni Martin, Lasky-Su Jessica, Weiss Scott T, Gerhard Glenn S, Still Christopher, Melka Melkaey M, Pausova Zdenka, Paus Tomáš, Grant Struan F A, Hakonarson Hakon, Price R Arlen, Wang Kai, Scherag Andre, Hebebrand Johannes, Hinney Anke, Franks Paul W, Frayling Timothy M, McCarthy Mark I, Hirschhorn Joel N, Loos Ruth J, Ingelsson Erik, Gerstein Hertzel C, Yusuf Salim, Beyene Joseph, Anand Sonia S, Meyre David
Abstract excerpt
Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) ≥ 40 kg/m(2)], but their contribution to common obesity (BMI ≥ 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclear. To fill this gap, we collected phenotypic and genetic data in up to 331 175 individuals from diverse ethnic groups. This process involved a systematic review of the...