Article

MANY PATHS TO DESTRUCTION: FAMILY-SPECIFIC TURNOVER AND STRESS RESPONSES FOR TRNA INTRONS

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> In organisms ranging from Archaea to humans, a subset of genes encoding tRNAs contain introns. Upon splicing, the tRNA exons are joined and the released free introns are rapidly degraded. Although tRNAs introns were previously considered to be “junk” sequences, we recently reported that free tRNA introns (fitRNAs) of S. cerevisiae serve as negative regulators of the cellular levels of mRNAs tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e77f1f9a-97bb-55b8-992f-224f2f41a44a
DOI: 10.1101/2025.11.19.689297

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MANY PATHS TO DESTRUCTION: FAMILY-SPECIFIC TURNOVER AND STRESS RESPONSES FOR TRNA INTRONSDOI 10.1101/2025.11.19.689297Read

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Semantic proximity Read

Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability.Semantic proximity Read

Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavageSemantic proximity Read

Molecular determinants of metazoan tricRNA biogenesisSemantic proximity Read

Introns regulate RNA and protein abundance in yeast.Semantic proximity Read

Disrupted tRNA gene diversity and possible evolutionary scenarios.Semantic proximity Read

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.Semantic proximity Read

Mammalian introns: when the junk generates molecular diversity.Semantic proximity Read

Reconstitution of the Human tRNA Splicing Endonuclease Complex: insight into the regulation of pre-tRNA cleavageSemantic proximity Read

Eukaryotic tRNA ligases mediate RNA break repairSemantic proximity Read

Long-read direct RNA sequencing of the mitochondrial transcriptome of <i>Saccharomyces cerevisiae</i> reveals condition-dependent intron turnoverSemantic proximity Read

Genetic and Biochemical Assays Reveal a Key Role for Replication Restart Proteins in Group II Intron RetrohomingSemantic proximity Read