Article
Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans.
Kidney international - 1 Feb 2015
Lorthioir Aurélien, Joannidès Robinson, Rémy-Jouet Isabelle, Fréguin-Bouilland Caroline, Iacob Michèle, Roche Clothilde, Monteil Christelle, Lucas Danièle, Renet Sylvanie, Audrézet Marie-Pierre, Godin Michel, Richard Vincent, Thuillez Christian, Guerrot Dominique, Bellien Jérémy
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calcium-induced nitric oxide release, prevented by dopamine receptor stimulation. However, the impact...
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