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Article

cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2012

Burgoyne Joseph Robert, Prysyazhna Oleksandra, Rudyk Olena, Eaton Philip

Abstract excerpt

Protein kinase G (PKG) is activated by nitric oxide (NO)-induced cGMP binding or alternatively by oxidant-induced interprotein disulfide formation. We found preactivation with cGMP attenuated PKG oxidation. 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) blockade of cGMP production increased disulfide PKG to 13 ± 2% and 29±4% of total in aorta and mesenteries, respectively. This was potentially anomalous,...

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Identifiers

PMID: 23006734
DOI: 10.1161/HYPERTENSIONAHA.112.198754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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