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Article

Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion.

American journal of hematology - 1 Mar 2021

Denton Christopher C, Shah Payal, Suriany Silvie, Liu Honglei, Thuptimdang Wanwara, Sunwoo John, Chalacheva Patjanaporn, Veluswamy Saranya, Kato Roberta, Wood John C, Detterich Jon A, Khoo Michael C K, Coates Thomas D

Abstract excerpt

Alpha thalassemia is a hemoglobinopathy due to decreased production of the α-globin protein from loss of up to four α-globin genes, with one or two missing in the trait phenotype. Individuals with sickle cell disease who co-inherit the loss of one or two α-globin genes have been known to have reduced risk of morbid outcomes, but the underlying mechanism is unknown. While α-globin gene deletions affect sickle red...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33247606
DOI: 10.1002/ajh.26058
PMCID: PMC10653668

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