Article
Hydroxyurea does not reverse functional alterations of the nitric oxide-cGMP pathway associated with priapism phenotype in corpus cavernosum from sickle cell mouse.
PloS one - 1 Jan 2023
Pereira Dalila Andrade, Pereira Danillo Andrade, da Silva Pereira Pamela, Silveira Tammyris Helena Rebecchi, Calmasini Fabiano Beraldi, Reis Leonardo Oliveira, Costa Fernando Ferreira, Silva Fábio Henrique
Abstract excerpt
Sickle cell disease (SCD) is a genetic disorder that has been associated with priapism. The role of hydroxyurea, a common SCD therapy, in influencing the nitric oxide (NO)-cGMP pathway and its effect on priapism is unclear. To investigate the effect of hydroxyurea treatment on smooth muscle relaxation of corpus cavernosum induced by stimulation of the NO-cGMP pathway in SCD transgenic mice and endothelial NO...
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