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Article

A polymorphism in the protein kinase C gene PRKCB is associated with α2-adrenoceptor-mediated vasoconstriction.

Pharmacogenetics and genomics - 1 Mar 2013

Posti Jussi P, Salo Perttu, Ruohonen Saku, Valve Laura, Muszkat Mordechai, Sofowora Gbenga G, Kurnik Daniel, Stein C Michael, Perola Markus, Scheinin Mika, Snapir Amir

Abstract excerpt

OBJECTIVES: α2-Adrenoceptors (α2-AR) mediate both constriction and dilatation of blood vessels. There is considerable interindividual variability in dorsal hand vein (DHV) constriction responses to α2-AR agonist activation. Genetic factors appear to contribute significantly to this variation. The present study was designed to identify the genetic factors contributing toward the interindividual variability in...

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Source

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Identifiers

PMID: 23337848
DOI: 10.1097/FPC.0b013e32835d247f
PMCID: PMC3912740

Genes

PRKCB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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