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Article

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades.

Circulation research - 10 Apr 2009

AbouAlaiwi Wissam A, Takahashi Maki, Mell Blair R, Jones Thomas J, Ratnam Shobha, Kolb Robert J, Nauli Surya M

Abstract excerpt

Cardiovascular complications such as hypertension are a continuous concern in patients with autosomal dominant polycystic kidney disease (ADPKD). The PKD2 encoding for polycystin-2 is mutated in approximately 15% of ADPKD patients. Here, we show that polycystin-2 is localized to the cilia of mouse and human vascular endothelial cells. We demonstrate that the normal expression level and localization of...

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Topics

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Share to Calcium Signaling
Share to Calmodulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Polycystic Kidney, Autosomal Dominant

Share to Protein Kinase C

Share to Stress, Mechanical

Share to TRPP Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 19265036
DOI: 10.1161/CIRCRESAHA.108.192765
PMCID: PMC3085025

Genes

PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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