Article
Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone.
American journal of physiology. Heart and circulatory physiology - 1 Jan 2013
Brookes Zoë L S, Ruff Lewis, Upadhyay Viralkumar S, Huang Linghong, Prasad Sony, Solanky Tirupa, Nauli Surya M, Ong Albert C M
Abstract excerpt
Patients with autosomal dominant polycystic kidney disease have a high prevalence of hypertension and structural vascular abnormalities, such as intracranial aneurysms. Hypertension can develop in childhood and often precedes a significant reduction in the glomerular filtration rate. The major aim of this study was to investigate whether a primary endothelial defect or a vascular smooth muscle (VSM) defect was...
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