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Article

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.

Neuro-oncology - 1 Dec 2014

Wiestler Benedikt, Capper David, Hovestadt Volker, Sill Martin, Jones David T W, Hartmann Christian, Felsberg Joerg, Platten Michael, Feiden Wolfgang, Keyvani Kathy, Pfister Stefan M, Wiestler Otmar D, Meyermann Richard, Reifenberger Guido, Pietsch Thorsten, von Deimling Andreas, Weller Michael, Wick Wolfgang

Abstract excerpt

BACKGROUND: Molecular biomarkers including isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation, 1p/19q codeletion, and O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation may improve prognostication and guide treatment decisions for patients with World Health Organization (WHO) anaplastic gliomas. At present, each marker is individually tested by distinct assays. Illumina Infinium...

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Identifiers

PMID: 25028501
DOI: 10.1093/neuonc/nou138
PMCID: PMC4232086

Genes

MGMT
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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