Article
Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in isocitrate dehydrogenase mutant glioma.
Neuro-oncology - 2 Nov 2023
Mamatjan Yasin, Voisin Mathew R, Nassiri Farshad, Moraes Fabio Y, Bunda Severa, So Jonathan, Salih Mira, Shirahata Mitsuaki, Ono Takahiro, Shimizu Hiroaki, Schrimpf Daniel, von Deimling Andreas, Aldape Kenneth D, Zadeh Gelareh
Abstract excerpt
BACKGROUND: Diffuse gliomas represent over 80% of malignant brain tumors ranging from low-grade to aggressive high-grade lesions. Within isocitrate dehydrogenase (IDH)-mutant gliomas, there is a high variability in survival and a need to more accurately predict outcome. METHODS: To identify and characterize a predictive signature of outcome in gliomas, we utilized an integrative molecular analysis (using...
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