Article
MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status.
Acta neuropathologica - 1 Oct 2012
Bady Pierre, Sciuscio Davide, Diserens Annie-Claire, Bloch Jocelyne, van den Bent Martin J, Marosi Christine, Dietrich Pierre-Yves, Weller Michael, Mariani Luigi, Heppner Frank L, Mcdonald David R, Lacombe Denis, Stupp Roger, Delorenzi Mauro, Hegi Monika E
Abstract excerpt
The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and epigenetic features of this intriguingly distinct behavior requires accurate MGMT classification to assess high...
Topics
- Brain Neoplasms
- CpG Islands
- DNA Methylation
- DNA Modification Methylases
- DNA Repair Enzymes
- Data Mining
- Gene Silencing
- Glioblastoma