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MGMT promoter methylation is associated with patient age and 1p/19q status in IDH-mutant gliomas

10 Feb 2021

Abstract excerpt

Methylation of the promoter region of the gene encoding O6-methylguanine-DNA methyltransferase (MGMT) predicts better response to the alkylating chemotherapeutic temozolomide (TMZ) in glioblastomas (GBM).1 Testing for MGMT promoter methylation is therefore required for World Health Organization (WHO) grade 4 GBMs, whereas in grade 2-3 gliomas, testing is more variable between institutions. Mutations in isocitrate...

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PMID: 33830235
DOI: 10.1093/neuonc/noab039

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