Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.

The Journal of general virology - 1 Nov 2014

Fan Jiyun, Wang Ying, Xiong Hui, Guo Xiaokui, Cheng Yung-Chi

Abstract excerpt

A high prevalence of the rtI187V polymerase substitution of hepatitis B virus (HBV) was detected in nucleoside/nucleotide-analogue-naive and -treated chronic hepatitis B (CHB) patients. We aimed at assessing the replicative capacity and susceptibility to lamivudine (LAM) and adefovir (ADV) in vitro of HBV harbouring rtI187V alone or in conjunction with LAM- or ADV-resistant mutations. The reverse transcriptase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to DNA Replication
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatitis B, Chronic

Share to Lamivudine

Share to Organophosphonates

Share to RNA-Directed DNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 25028473
DOI: 10.1099/vir.0.066886-0
PMCID: PMC4202270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.PMID 25028473Read ↗

Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.Semantic proximity Read ↗

Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.Semantic proximity Read ↗

The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil.Semantic proximity Read ↗

Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.Semantic proximity Read ↗

Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.Semantic proximity Read ↗

rtM204Q may serve as a novel lamivudine-resistance-associated mutation of hepatitis B virus.Semantic proximity Read ↗

Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy.Semantic proximity Read ↗

The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.Semantic proximity Read ↗

The Impact of the Hepatitis B Virus Polymerase rtA181T Mutation on Replication and Drug Resistance Is Potentially Affected by Overlapping Changes in Surface GeneSemantic proximity Read ↗

Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.Semantic proximity Read ↗

Impacts of HBV rtH55R polymerase substitution on viral replication and rtM204I/V resistance to nucleoside/nucleotide antiviral drugs.Semantic proximity Read ↗

[Clinical emergence features and implications of hepatitis B virus rtA181T mutation].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.