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Article

Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.

Antiviral research - 1 Aug 2020

Chen Rongjuan, Liu Yan, Luo Dan, Si Lanlan, Huang Bixia, Wang Jun, Li Xiaodong, Cheng Fengjuan, Xu Dongping, Duan Changzhu

Abstract excerpt

The study aimed to characterize the prevalence and virological features of the rtA181S + T184I + M204I mutant in a large cohort of patients with chronic HBV infection. In total, 22,009 nucleoside/nucleotide analog-treated patients who underwent resistance testing at the Fifth Medical Center of Chinese PLA General Hospital between 2007 and 2016 were enrolled. Serum samples were collected for HBV...

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PMID: 32569703
DOI: 10.1016/j.antiviral.2020.104852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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