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Article

Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy.

Antiviral therapy - 1 Jan 2016

Liu Yan, Xin Shaojie, Ye Xiaoling, Chen Rongjuan, Xu Zhihui, Li Xiaodong, Ye Haiyan, Cheng Shuquan, Xu Dongping

Abstract excerpt

BACKGROUND: The study aimed to clarify whether the rtI233V substitution affects adefovir (ADV) resistance. METHODS: A total of 18,419 patients from Beijing 302 Hospital were investigated. HBV complete reverse transcriptase region of the polymerase was screened by direct sequencing and verified by clonal sequencing if necessary. Replication-competent wild-type and mutant HBV genomic amplicons were transfected into...

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Source

Identifiers

PMID: 26079809
DOI: 10.3851/IMP2971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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