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Article

rtM204Q may serve as a novel lamivudine-resistance-associated mutation of hepatitis B virus.

PloS one - 1 Jan 2014

Liu Yan, Xu Zhihui, Wang Yan, Li Xiaodong, Liu Liming, Chen Li, Xin Shaojie, Xu Dongping

Abstract excerpt

BACKGROUND AND AIMS: Lamivudine (LAM) is still widely used for anti-HBV therapy in China. The study aimed to clarify whether a newly-found rtM204Q mutation from patients was associated with the drug resistance. METHODS: HBV complete reverse-transcriptase region was screened by direct sequencing and verified by clonal sequencing. Replication-competent plasmids containing patient-derived 1.1mer mutant or wild-type...

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Share to Antiviral Agents
Share to Drug Resistance, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24586482
DOI: 10.1371/journal.pone.0089015
PMCID: PMC3933355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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