Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.

Journal of virology - 1 Nov 2003

Delaney William E, Yang Huiling, Westland Christopher E, Das Kalyan, Arnold Eddy, Gibbs Craig S, Miller Michael D, Xiong Shelly

Abstract excerpt

Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif (reverse transcriptase [rt] mutations rtM204V/I) conferred resistance to lamivudine as well as reducing the in vitro replication efficiency of HBV. A second mutation, rtL180M, was previously reported to partially restore...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Aminopurine
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Lamivudine

Share to Reverse Transcriptase Inhibitors

Share to RNA-Directed DNA Polymerase

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 14557667
DOI: 10.1128/jvi.77.21.11833-11841.2003
PMCID: PMC229343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.PMID 14557667Read ↗

Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.Semantic proximity Read ↗

Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case.Semantic proximity Read ↗

The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutationSemantic proximity Read ↗

Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.Semantic proximity Read ↗

YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.Semantic proximity Read ↗

Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy.Semantic proximity Read ↗

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group.Semantic proximity Read ↗

Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.Semantic proximity Read ↗

Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.Semantic proximity Read ↗

Dynamics of Hepatitis B Virus Resistance to LamivudineSemantic proximity Read ↗

rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy.Semantic proximity Read ↗

Long-term follow-up of chronic hepatitis B after the emergence of mutations in the hepatitis B virus polymerase region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.