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Article

Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.

Journal of hepatology - 1 Oct 2009

Amini-Bavil-Olyaee Samad, Herbers Ulf, Mohebbi Seyed Reza, Sabahi Farzaneh, Zali Mohammad Reza, Luedde Tom, Trautwein Christian, Tacke Frank

Abstract excerpt

BACKGROUND/AIMS: The rtQ215S mutation in the hepatitis B virus (HBV) polymerase has been described as a secondary mutation associated with resistance to lamivudine (LAM) and adefovir (ADV). We aimed at assessing the prevalence of substitutions at rtQ215 of the HBV polymerase and determining the molecular and functional consequences using phenotypic analyses in vitro. METHODS: The polymerase region was directly...

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Identifiers

PMID: 19586679
DOI: 10.1016/j.jhep.2009.04.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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