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Article

RhoA mutations identified in diffuse gastric cancer.

Cancer cell - 14 Jul 2014

Zhou Jin, Hayakawa Yoku, Wang Timothy C, Bass Adam J

Abstract excerpt

The diffuse-type histologic variant of gastric cancer is characterized by highly invasive growth patterns and lack of cellular cohesion. Two recent studies have identified highly recurrent mutations of the gene encoding the small GTPase RhoA and suggest that RhoA activity may have a tumor suppressive role in this disease.

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Source

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Identifiers

PMID: 25026207
DOI: 10.1016/j.ccr.2014.06.022
PMCID: PMC4206186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RhoA mutations identified in diffuse gastric cancer.PMID 25026207Read ↗

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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.Semantic proximity Read ↗

A New Rho(d) Map to Diffuse Gastric Cancer.Semantic proximity Read ↗

Identification of New Pathogenic Variants of Hereditary Diffuse Gastric Cancer.Semantic proximity Read ↗

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RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancerSemantic proximity Read ↗

RHOA drivers take alternate routes in gastric cancer.Semantic proximity Read ↗

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