Article
Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells.
Biochemical and biophysical research communications - 8 Jan 2018
Miyamoto Shingo, Nagamura Yuko, Nakabo Ayaka, Okabe Akira, Yanagihara Kazuyoshi, Fukami Kiyoko, Sakai Ryuichi, Yamaguchi Hideki
Abstract excerpt
RhoA is a member of Rho family small GTPases that regulates diverse cellular functions. Recent large-scale sequencing studies have identified recurrent somatic mutations of RHOA in diffuse-type gastric carcinoma (DGC), indicating that RHOA is a driver of DGC. In this study, we investigated the possible abnormalities of RHOA in a panel of gastric carcinoma (GC) cell lines. Pulldown assay and immunoblot analysis...
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