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Article

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.

Nature genetics - 1 Jun 2014

Kakiuchi Miwako, Nishizawa Takashi, Ueda Hiroki, Gotoh Kengo, Tanaka Atsushi, Hayashi Akimasa, Yamamoto Shogo, Tatsuno Kenji, Katoh Hiroto, Watanabe Yoshiaki, Ichimura Takashi, Ushiku Tetsuo, Funahashi Shinichi, Tateishi Keisuke, Wada Ikuo, Shimizu Nobuyuki, Nomura Sachiyo, Koike Kazuhiko, Seto Yasuyuki, Fukayama Masashi, Aburatani Hiroyuki, Ishikawa Shumpei

Abstract excerpt

Diffuse-type gastric carcinoma (DGC) is characterized by a highly malignant phenotype with prominent infiltration and stromal induction. We performed whole-exome sequencing on 30 DGC cases and found recurrent RHOA nonsynonymous mutations. With validation sequencing of an additional 57 cases, RHOA mutation was observed in 25.3% (22/87) of DGCs, with mutational hotspots affecting the Tyr42, Arg5 and Gly17 residues...

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Source

Identifiers

PMID: 24816255
DOI: 10.1038/ng.2984

Genes

RHOA
RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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