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Article

Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers.

Genes, chromosomes & cancer - 1 Mar 2005

Morris Leah E, Bloom George S, Frierson Henry F, Powell Steven M

Abstract excerpt

IQGAP1 is recognized as a negative regulator of cell-cell adhesion at adherens junctions in several cell types, including gastric mucosal cells. The histopathologic appearance of diffuse gastric carcinoma is defined by non- or poorly cohesive tumor cells, indicating abnormal intercellular adhesion. Hence, we screened 38 gastric cancers for activating point mutations in IQGAP1. In 2 of the 33 diffuse gastric...

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Identifiers

PMID: 15611933
DOI: 10.1002/gcc.20150

Genes

IQGAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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