Article
Variegated RHOA mutations in human cancers.
Experimental hematology - 1 Dec 2016
Kataoka Keisuke, Ogawa Seishi
Abstract excerpt
RHOA is one of the most extensively investigated members of the Rho GTPase family of proteins and has long been implicated in malignant transformation as well as tumor invasion and metastasis. Recently, revolutionized sequencing platforms have revealed frequent RHOA mutations in a wide variety of human cancers, including angio-immunoblastic T-cell lymphoma, adult T-cell leukemia/lymphoma, germinal center B-cell...
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