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Article

Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.

PloS one - 1 Jan 2014

Lutz Stefan Z, Franck Olga, Böhm Anja, Machann Jürgen, Schick Fritz, Machicao Fausto, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

AIMS/HYPOTHESIS: Recently, cardiotrophin-1, a member of the interleukin-6 family of cytokines was described to protect beta-cells from apoptosis, to improve glucose-stimulated insulin secretion and insulin resistance, and to prevent streptozotocin-induced diabetes in mice. Here, we studied whether common single nucleotide polymorphisms (SNPs) in the CTF1 locus, encoding cardiotrophin-1, influence insulin...

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Source

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Identifiers

PMID: 25025664
DOI: 10.1371/journal.pone.0100391
PMCID: PMC4099130

Genes

CTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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