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Article

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans.

Scientific reports - 17 May 2018

Lutz Stefan Z, Falcenberg Mathias, Machicao Fausto, Peter Andreas, Kächele Martin, Randrianarisoa Elko, Lehn-Stefan Angela, Wagner Robert, Machann Jürgen, Schick Fritz, Heni Martin, Ullrich Axel, Fritsche Andreas, Stefan Norbert, Häring Hans-Ulrich, Staiger Harald, Kantartzis Konstantinos

Abstract excerpt

Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in...

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Share to Cardiovascular Abnormalities
Share to Carotid Intima-Media Thickness
Share to Cholesterol, LDL
Share to Diabetes Mellitus, Type 2
Share to Insulin
Share to Insulin Resistance
Share to Lipids
Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 29773828
DOI: 10.1038/s41598-018-26055-7
PMCID: PMC5958094

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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