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Article

The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans.

Clinical science (London, England : 1979) - 1 Mar 2009

Kantartzis Konstantinos, Machicao Fausto, Machann Jürgen, Schick Fritz, Fritsche Andreas, Häring Hans-Ulrich, Stefan Norbert

Abstract excerpt

The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis. Mice overexpressing hepatic DGAT2 fed a high-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance. In the present study, we investigated whether such a phenotype also exists in humans. For this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18980578
DOI: 10.1042/CS20080306

Genes

DGAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans.PMID 18980578Read ↗

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