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Article

Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels.

PloS one - 1 Jan 2012

Böhm Anja, Ordelheide Anna-Maria, Machann Jürgen, Heni Martin, Ketterer Caroline, Machicao Fausto, Schick Fritz, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

OBJECTIVE: Pigment epithelium-derived factor (PEDF) belongs to the serpin family of peptidase inhibitors (serpin F1) and is among the most abundant glycoproteins secreted by adipocytes. In vitro and mouse in vivo data revealed PEDF as a candidate mediator of obesity-induced insulin resistance. Therefore, we assessed whether common genetic variation within the SERPINF1 locus contributes to adipose tissue-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22457810
DOI: 10.1371/journal.pone.0034035
PMCID: PMC3311576

Genes

SERPINF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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