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Article

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.

PloS one - 1 Jan 2013

Staiger Harald, Böhm Anja, Scheler Mika, Berti Lucia, Machann Jürgen, Schick Fritz, Machicao Fausto, Fritsche Andreas, Stefan Norbert, Weigert Cora, Krook Anna, Häring Hans-Ulrich, de Angelis Martin Hrabě

Abstract excerpt

AIMS/HYPOTHESIS: Recently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. Here, we assessed whether common single nucleotide polymorphisms (SNPs) in the FNDC5 locus, encoding the irisin precursor, contribute to human prediabetic phenotypes (overweight, glucose intolerance, insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23637927
DOI: 10.1371/journal.pone.0061903
PMCID: PMC3636229

Genes

FNDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.PMID 23637927Read ↗

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