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Article

Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data.

Bioinformatics (Oxford, England) - 15 Dec 2014

Boeva Valentina, Popova Tatiana, Lienard Maxime, Toffoli Sebastien, Kamal Maud, Le Tourneau Christophe, Gentien David, Servant Nicolas, Gestraud Pierre, Rio Frio Thomas, Hupé Philippe, Barillot Emmanuel, Laes Jean-François

Abstract excerpt

MOTIVATION: Because of its low cost, amplicon sequencing, also known as ultra-deep targeted sequencing, is now becoming widely used in oncology for detection of actionable mutations, i.e. mutations influencing cell sensitivity to targeted therapies. Amplicon sequencing is based on the polymerase chain reaction amplification of the regions of interest, a process that considerably distorts the information on copy...

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Identifiers

PMID: 25016581
DOI: 10.1093/bioinformatics/btu436
PMCID: PMC4253825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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