Article

Minimum Error Calibration and Normalization for Genomic Copy Number Analysis

2019-07-31

Abstract excerpt

Copy number variations (CNV) are regional deviations from the normal autosomal bi-allelic DNA content. While germline CNVs are a major contributor to genomic syndromes and inherited diseases, the majority of cancers accumulate extensive “somatic” CNV (sCNV or CNA) during the process of oncogenetic transformation and progression. While specific sCNV have closely been associated with tumorigenesis, intriguingly many...

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Literature Corpus work: db5d5fa8-14fe-5296-ae01-321e3ca2bee0
DOI: 10.1101/720854

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