Article
Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2011
Strasser Andrew A, Benowitz Neal L, Pinto Angela G, Tang Kathy Z, Hecht Stephen S, Carmella Steve G, Tyndale Rachel F, Lerman Caryn E
Abstract excerpt
BACKGROUND: Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites cotinine and 3'-hydroxycotinine (referred to as the nicotine metabolism ratio; NMR). We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total...
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