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Article

Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Jun 2011

Falcone Mary, Jepson Christopher, Benowitz Neal, Bergen Andrew W, Pinto Angela, Wileyto E Paul, Baldwin Don, Tyndale Rachel F, Lerman Caryn, Ray Riju

Abstract excerpt

INTRODUCTION: Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking. The nicotine metabolite ratio (NMR), a measure of the rate of nicotine metabolism, is associated with the number of cigarettes per day (CPD) and likelihood of cessation. We tested the potential interacting effects of these two risk factors on CPD. METHODS:...

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Source

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Identifiers

PMID: 21385908
DOI: 10.1093/ntr/ntr012
PMCID: PMC3103715

Genes

CPD
CHRNA5
CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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