Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance.

Pharmacogenetics and genomics - 1 Jul 2021

Liakoni Evangelia, Tyndale Rachel F, Jacob Peyton, Dempsey Delia A, Addo Newton, Benowitz Neal L

Abstract excerpt

OBJECTIVES: To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3'-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of nicotine, cotinine and 3'-hydroxycotinine glucuronidation and UGT genotypes. METHODS: Participants [Caucasians (Whites), African Americans (Blacks) and Asian-Americans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Cotinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Glucuronides

Share to Glucuronosyltransferase

Share to Nicotine

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 33675323
DOI: 10.1097/FPC.0000000000000427
PMCID: PMC8184575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance.PMID 33675323Read ↗

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies.Semantic proximity Read ↗

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.Semantic proximity Read ↗

Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.Semantic proximity Read ↗

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.Semantic proximity Read ↗

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex.Semantic proximity Read ↗

A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine.Semantic proximity Read ↗

Reproducibility of the nicotine metabolite ratio in cigarette smokers.Semantic proximity Read ↗

Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.Semantic proximity Read ↗

Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers.Semantic proximity Read ↗

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activitySemantic proximity Read ↗

Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.Semantic proximity Read ↗

The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.