Article
DNA methylation profiles of long- and short-term glioblastoma survivors.
Epigenetics - 1 Feb 2013
Shinawi Thoraia, Hill Victoria K, Krex Dietmar, Schackert Gabriele, Gentle Dean, Morris Mark R, Wei Wenbin, Cruickshank Garth, Maher Eamonn R, Latif Farida
Abstract excerpt
Glioblastoma (GBM) is the most common and malignant type of primary brain tumor in adults and prognosis of most GBM patients is poor. However, a small percentage of patients show a long term survival of 36 mo or longer after diagnosis. Epigenetic profiles can provide molecular markers for patient prognosis: recently, a G-CIMP positive phenotype associated with IDH1 mutations has been described for GBMs with good...
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