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Article

Molecular subtypes of glioblastoma are relevant to lower grade glioma.

PloS one - 1 Jan 2014

Guan Xiaowei, Vengoechea Jaime, Zheng Siyuan, Sloan Andrew E, Chen Yanwen, Brat Daniel J, O'Neill Brian Patrick, de Groot John, Yust-Katz Shlomit, Yung Wai-Kwan Alfred, Cohen Mark L, Aldape Kenneth D, Rosenfeld Steven, Verhaak Roeland G W, Barnholtz-Sloan Jill S

Abstract excerpt

BACKGROUND: Gliomas are the most common primary malignant brain tumors in adults with great heterogeneity in histopathology and clinical course. The intent was to evaluate the relevance of known glioblastoma (GBM) expression and methylation based subtypes to grade II and III gliomas (ie. lower grade gliomas). METHODS: Gene expression array, single nucleotide polymorphism (SNP) array and clinical data were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24614622
DOI: 10.1371/journal.pone.0091216
PMCID: PMC3948818

Genes

IDH1
EGFR
PTEN

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