Article

Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia from Non-Malignant Clonal Hematopoiesis

2020-10-26

Abstract excerpt

Genetic mutations associated with acute myeloid leukemia can also be detected in age-related clonal hematopoiesis, making confident assignment of detected variants to malignancy challenging particularly in the post-treatment setting. This has implications for measurable residual disease monitoring, where the relationship between sequencing and flow cytometry is also imperfect. We show, using whole-genome-sequencin...

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Literature Corpus work: 8ecd4041-03b7-5d18-8680-8a68b1d4a95e
DOI: 10.1101/2020.10.22.20216028

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