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Fine-tuning AMPK in physiology and disease using point-mutant mouse models

1 Aug 2024

Abstract excerpt

AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that monitors the cellular energy status to adapt it to the fluctuating nutritional and environmental conditions in an organism. AMPK plays an integral part in a wide array of physiological processes, such as cell growth, autophagy and mitochondrial function, and is implicated in diverse diseases, including cancer,...

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PMID: 39136185
DOI: 10.1242/dmm.050798

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