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Article

Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.

Biochemical Society transactions - 1 Feb 2003

Mu J, Barton E R, Birnbaum M J

Abstract excerpt

AMP-activated protein kinase (AMPK) is becoming recognized as a critical regulator of energy metabolism in cells. Using a mouse model in which we specifically blocked AMPK activity in muscles, we have demonstrated that activation of AMPK is necessary for the effects of 5-aminoimidazole-4-carboxamide riboside ('AICAR') and hypoxia, and is possibly required for a portion of exercise-induced glucose uptake. These...

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PMID: 12546693
DOI: 10.1042/bst0310236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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