Article
Hearts lacking plasma membrane KATP channels display changes in basal aerobic metabolic substrate preference and AMPK activity.
American journal of physiology. Heart and circulatory physiology - 1 Sept 2017
Youssef Nermeen, Campbell Scott, Barr Amy, Gandhi Manoj, Hunter Beth, Dolinsky Vernon, Dyck Jason R B, Clanachan Alexander S, Light Peter E
Abstract excerpt
Cardiac ATP-sensitive K+ (KATP) channels couple changes in cellular metabolism to membrane excitability and are activated during metabolic stress, although under basal aerobic conditions, KATP channels are thought to be predominately closed. Despite intense research into the roles of KATP channels during metabolic stress, their contribution to aerobic basal cardiac metabolism has not been previously investigated....
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