Article
Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation.
Neuro-oncology - 1 Dec 2014
Jha Prerana, Pia Patric Irene Rosita, Shukla Sudhanshu, Pathak Pankaj, Pal Jagriti, Sharma Vikas, Thinagararanjan Sivaarumugam, Santosh Vani, Suri Vaishali, Sharma Mehar Chand, Arivazhagan Arimappamagan, Suri Ashish, Gupta Deepak, Somasundaram Kumaravel, Sarkar Chitra
Abstract excerpt
BACKGROUND: Pediatric glioblastoma multiforme (GBM) is rare, and there is a single study, a seminal discovery showing association of histone H3.3 and isocitrate dehydrogenase (IDH)1 mutation with a DNA methylation signature. The present study aims to validate these findings in an independent cohort of pediatric GBM, compare it with adult GBM, and evaluate the involvement of important functionally altered...
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