Clinicopathological and molecular landscape of 5-year IDH-wild-type glioblastoma survivors: A multicentric retrospective study.

doi:10.1016/j.canlet.2024.216711

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Article

Clinicopathological and molecular landscape of 5-year IDH-wild-type glioblastoma survivors: A multicentric retrospective study.

Cancer letters - 28 Apr 2024

Miele Evelina, Anghileri Elena, Calatozzolo Chiara, Lazzarini Elisabetta, Patrizi Sara, Ciolfi Andrea, Pedace Lucia, Patanè Monica, Abballe Luana, Paterra Rosina, Maddaloni Luisa, Barresi Sabina, Mastronuzzi Angela, Petruzzi Alessandra, Tramacere Irene, Farinotti Mariangela, Gurrieri Lorena, Pirola Elena, Scarpelli Mauro, Lombardi Giuseppe, Villani Veronica, Simonelli Matteo, Merli Rossella, Salmaggi Andrea, Tartaglia Marco, Silvani Antonio, DiMeco Francesco, Calistri Daniele, Lamperti Elena, Locatelli Franco, Indraccolo Stefano, Pollo Bianca

Abstract excerpt

Five-year glioblastoma (GBM) survivors (LTS) are the minority of the isocitrate dehydrogenase (IDH)-wild-type GBM patients, and their molecular fingerprint is still largely unexplored. This multicenter retrospective study analyzed a large LTS-GBM cohort from nine Italian institutions and molecularly characterized a subgroup of patients by mutation, DNA methylation (DNAm) and copy number variation (CNV) profiling,...

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PMID: 38423245
DOI: 10.1016/j.canlet.2024.216711

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