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Article

Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.

Gut - 1 May 2015

Fitzmaurice Karen, Hurst Jacob, Dring Megan, Rauch Andri, McLaren Paul J, Günthard Huldrych F, Gardiner Clair, Klenerman Paul

Abstract excerpt

BACKGROUND: Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are strongly associated with spontaneous clearance and treatment outcomes. OBJECTIVE: This study investigates the importance of HLA genes in the context of genetic variation...

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Share to Adaptive Immunity
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to HLA-A3 Antigen

Share to HLA-B27 Antigen

Share to HLA-C Antigens

Share to Interleukins

Share to Receptors, KIR

Source

Open in PubMed Open full text

Identifiers

PMID: 24996883
DOI: 10.1136/gutjnl-2013-306287
PMCID: PMC4392199

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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