Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases.

doi:10.1371/journal.pone.0117420

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Article

Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases.

PloS one - 1 Jan 2015

De Re Valli, Caggiari Laura, De Zorzi Mariangela, Repetto Ombretta, Zignego Anna Linda, Izzo Francesco, Tornesello Maria Lina, Buonaguro Franco Maria, Mangia Alessandra, Sansonno Domenico, Racanelli Vito, De Vita Salvatore, Pioltelli Pietro, Vaccher Emanuela, Berretta Massimiliano, Beretta Massimiliano, Mazzaro Cesare, Libra Massimo, Gini Andrea, Zucchetto Antonella, Cannizzaro Renato, De Paoli Paolo

Abstract excerpt

BACKGROUND: The variability in the association of host innate immune response to Hepatitis C virus (HCV) infection requires ruling out the possible role of host KIR and HLA genotypes in HCV-related disorders: therefore, we therefore explored the relationships between KIR/HLA genotypes and chronic HCV infection (CHC) as they relate to the risk of HCV-related hepatocarcinoma (HCC) or lymphoproliferative disease...

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PMID: 25700262
DOI: 10.1371/journal.pone.0117420
PMCID: PMC4336327

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